From the article "Disease and Death in the Nineteenth Century: A Genealogical Perspective",
by James Byars Carter, M.D. Exerpted from a complete article on the subject from
The National Genealogical Society Quarterly, Vol. 76, (Dec 1988) pp 289?301.


Most of the definitions of diagnoses in the glossary that follows are from medical dictionaries
or medical texts compiled at different points in the nineteenth  century. [see NOTES
AND REFERENCES at end of article].  To determine which medical terms should be defined, the
author has surveyed various mortality schedules, death certificates, and other medical
sources of the nineteenth century. While he has tried to submit the best?possible interpre-
tation of these terms, there are certainly other interpretations which may be valid.
Abscess. A localized collection of pus buried in tissues, organs, or confined spaces of the
body, often accompanied by swelling and inflammation and frequently caused by bacteria. The
brain, lung, or kidney (for instance) could be involved. See boil.
Addison's disease. A disease characterized by severe weakness, low blood pressure, and a
bronzed coloration of the skin, due to decreased secretion of cortisol from the adrenal gland.
Dr. Thomas Addison (1793?1860), born near Newcastle, England, described the disease in 1855.
Synonyms: Morbus addisonii, bronzed skin disease.
Ague. Malarial or intermittent fever characterized by paroxysms (stages of chills, fever, and
sweating at regularly recurring times) and followed by an interval or intermission whose length
determines the epithets: quotidian, tertian, quartan, and quintan ague (defined in the text).
Popularly, the disease was known as "fever and ague," "chill fever," "the shakes," and by names
expressive of the locality in which it was prevalent?? such as, "swamp fever" (in Louisiana),
"Panama fever," and "Chagres fever."
Ague?cake. A form of enlargement of the spleen, resulting from the action of malaria on the
Anasarca. Generalized massive dropsy. See dropsy.
Aphthae. See thrush.
Aphthous stomatitis. See canker.
Ascites. See dropsy.
Asthenia. See debility.
Bilious fever. A term loosely applied to certain enteric (intestinal) and malarial fevers. See
Biliousness. A complex of symptoms comprising nausea, abdominal discomfort, headache, and
constipation?? formerly attributed to excessive secretion of bile from the liver.
Boil. An abscess of skin or painful, circumscribed inflammation of the skin or a hair follicle,
having a dead, pus? forming inner core, usually caused by a staphylococcal infection. Synonym:
Brain fever. See meningitis, typhus.
Bronchial asthma. A paroxysmal, often allergic disorder of breathing, characterized by spasm of
the bronchial tubes of the lungs, wheezing, and difficulty in breathing air outward?? often
accompanied by coughing and a feeling of tightness in the chest. In the nineteenth century the
direct causes were thought to be dust, vegetable irritants, chemical vapors, animal emanations,
climatic influences, and bronchial inflammation?? all of which were reasonable guesses. The
indirect causes were thought to be transmissions by the nervous system or by the blood from
gout, syphilis, skin disease, renal disease, or heredity. Only the latter cause was a reasonable
Camp fever. See typhus.
Cancer. A malignant and invasive growth or tumor (especially tissue that covers a surface or
lines a cavity), tending to recur after excision and to spread to other sites. In the nineteenth
century, physicians noted that cancerous tumors tended to ulcerate, grew constantly, and
progressed to a fatal end and that there was scarcely a tissue they would not invade. Synonyms:
malignant growth, carcinoma.
Cancrum otis. A severe, destructive, eroding ulcer of the cheek and lip, rapidly proceeding to
sloughing. In the last century it was seen in delicate, ill?fed, ill?tended children between the
ages of two and five. The disease was the result of poor hygiene acting upon a debilitated
system. It commonly followed one of the eruptive fevers and was often fatal. The destructive
disease could, in a few days, lead to gangrene of the lips, cheeks, tonsils, palate, tongue, and
even half the face; teeth would fall from their sockets, and a horribly fetid saliva flowed from
the parts. Synonyms: canker, water canker, noma, gangrenous stomatitis, gangrenous ulceration of
the mouth.
Canker. An ulcerous sore of the mouth and lips, not considered fatal today. Synonym: aphthous
stomatitis. See cancrum otis.
Carcinoma. See cancer.
Catarrh. Inflammation of a mucous membrane, especially of the air passages of the head and
throat, with a free discharge. It is characterized by cough, thirst, lassitude, fever, watery
eyes, and increased secretions of mucus from the air passages. Bronchial catarrh was bronchitis;
suffocative catarrh was croup; urethral catarrh was gleet; vaginal catarrh was leukorrhea;
epidemic catarrh was the same as influenza. Synonyms: cold, coryza.
Childbirth. A cause given for many female deaths of the century. Almost all babies were born in
homes and usually were delivered by a family member or a midwife; thus infection and lack of
medical skill were often the actual causes of death.
Cholera. An acute, infectious disease, endemic in India and China and now occasionally epidemic
elsewhere characterized by profuse diarrhea, vomiting, and cramps. It is caused by a potent
toxin discharged by the bacterium Vibrio cholerae, which acts on the small intestine to cause
secretion of large amounts of fluid. The painless, watery diarrhea and the passing of rice-
water stool are characteristic. Great body salt depletion occurs. Cholera is spread by feces
contaminated water and food. Major epidemics struck the United States in the years 1832, 1849,
and 1866. In the 1830s the causes were generally thought to be intemperance in the use of ardent
spirits or drinking bad water; uncleanness, poor living or crowded and ill ventilated dwellings;
and too much fatigue. By 1850 cholera was thought to be caused by putrid animal poison and
miasma or pestilential vapor rising from swamps and marshes or that it entered the body through
the lungs or was transmitted through the medium of clothing. It was still believed that it at-
tacked the poor, the dissolute, the diseased, and the fearful while the healthy, well-clad,
well-fed, and fearless man escaped the ravages of cholera.
Cholera infantum. A common, noncontagious diarrhea of young children, occurring in summer or
autumn. In the nineteenth century it was considered indigenous to the United States; was preva-
lent during the hot weather in most of the towns of the middle and southern states, as well as
many western areas; and was characterized by gastric pain, vomiting, purgation, fever, and pros-
tration. It was common among the poor and in handfed babies. Death frequently occurred in three
to five days. Synonyms: summer complaint, weaning brash, water gripes, choleric fever of
children, cholera morbus.
Chorea. Any of several diseases of the nervous system, characterized by jerky movements that
appear to be well coordinated but are performed involuntarily, chiefly of the face and extre-
mities. Synonym: Saint Vitus' dance.
Chronic. Persisting over a long period of time as opposed to acute or sudden. This word was
often the only one entered under "cause of death" in the mortality schedules.
Colic. Paroxysmal pain in the abdomen or bowels. Infantile colic is benign paroxysmal abdominal
pain during the first three months of life. Colic rarely caused death; but in the last century
a study reported that in cases of death, intussusception (the prolapse of one part of the intes-
tine into the lumen of an immediately adjoining part) occasionally occurred. Renal colic can
occur from disease in the kidney, gallstone colic from a stone in the bile duct.
Congestion. An excessive or abnormal accumulation of blood or other fluid in a body part or
blood vessel. In congestive fever (see text), the internal organs become gorged with blood.
Consumption. A wasting away of the body; formerly applied especially to pulmonary tuberculosis.
The disorder is now known to be an infectious disease caused by the bacterial species Myco-
bacterium tuberculosis.  Synonyms: marasmus (in the mid-nineteenth century), phthisis.
Convulsions. Severe contortion of the body caused by violent, involuntary muscular contractions
of the extremities, trunk, and head. See epilepsy.
Coryza. See catarrh.
Croup. Any obstructive condition of the larynx (voice box) or trachea (windpipe), characterized
by a hoarse, barking cough and difficult breathing occurring chiefly in infants and children.
The obstruction could be caused by allergy, a foreign body, infection, or new growth (tumor). In
the early nineteenth century it was called cynanche trachealis. The crouping noise was similar
to the sound emitted by a chicken affected with the pip, which in some parts of Scotland was
called roup; hence, probably, the term croup. Synonyms: roup, hives, choak, stuffing, rising of
the lights.
Debility. Abnormal bodily weakness or feebleness; decay of strength. This was a term descriptive
of a patient's condition and of no help in making a diagnosis. Synonym: asthenia.
Diphtheria. An acute infectious disease caused by toxigenic strains of the bacillus Coryne-
bacterium diphtheriae, acquired by contact with an infected person or a carrier of the disease.
It was usually confined to the upper respiratory tract (throat) and characterized by the
formation of a tough membrane (false membrane) attached firmly to the underlying tissue that
would bleed if forcibly removed. In the nineteenth century the disease was occasionally confused
with scarlet fever and croup.
Dropsy. A contraction for hydropsy. Edema, the presence of abnormally large amounts of fluid in
intercellular tissue spaces or body cavities. Abdominal dropsy is ascites; brain dropsy is hydro-
cephalus; and chest dropsy is hydrothorax. Cardiac dropsy is a symptom of disease of the heart
and arises from obstruction to the current of blood through the heart, lungs, or liver. Anasarca
is general fluid accumulation throughout the body.
Dysentery. A term given to a number of disorders marked by inflammation of the intestines
(especially of the colon) and attended by pain in the abdomen, by tenesmus (straining to
defecate without the ability to do so), and by frequent stools containing blood and mucus. The
causative agent may be chemical irritants, bacteria, protozoa, or parasitic worms. There are
two specific varieties: (1) amebic dysentery caused by the protozoan Entamoeba histolytica;
(2) bacillary dysentery caused by bacteria of the genus Shigella. Dysentery was one of the most
severe scourges of armies in the nineteenth century. The several forms of dysentery and diarrhea
accounted for more than one-fourth of all the cases of disease reported during the first
two years of the Civil War. Synonyms: flux, bloody flux, contagious pyrexia (fever), frequent
griping stools.
Eclampsia. A form of toxemia (toxins-or poisons-in the blood) accompanying pregnancy, character-
ized by albuminuria (protein in the urine), by hypertension (high blood pressure), and by
convulsions. In the last century, the term was used for any form of convulsion.
Edema. See dropsy.
Effluvia. Exhalations or emanations, applied especially to those of noxious character. In the
mid-nineteenth century, they were called "vapours" and distinguished into the contagious effluvia,
such as rubeolar (measles); marsh effluvia, such as miasmata; and those arising from animals
or vegetables, such as odors.
Emphysema, pulmonary. A chronic, irreversible disease of the lungs, characterized by abnormal
enlargement of air spaces in the lungs and accompanied by destruction of the tissue lining the
walls of the air sacs. By 1900 the condition was recognized as a chronic disease of the lungs
associated with marked dyspnea (shortness of breath), hacking cough, defective aeration
(oxygenation) of the blood, cyanosis (blue color of facial skin), and a full and rounded or
"barrel-shaped chest. This disease is now most commonly associated with tobacco smoking.
Enteric fever. See typhoid fever.
Epilepsy. A disorder of the nervous system, characterized either by mild, episodic loss of
attention or sleepiness (petittnal) or by severe convulsions with loss of consciousness
(grand mal). Synonyms: falling sickness, fits.
Erysipelas. An acute, febrile, infectious disease, caused by a specific group ~4 streptococcus
bacterium and characterized by a diffusely spreading, deep?red inflammation of the skin or
mucous membranes causing a rash with a well?defined margin. Synonyms: Rose, Saint Anthony's Fire
(from its burning heat or, perhaps, because Saint Anthony was supposed to cure it miraculously).
Flux. See dysentery.
Furuncle. See boil.
Gangrene. Death and decay of tissue in a part of the body??usually a limb due to injury,
disease, or failure of blood supply. Synonym: mortification.
Gleet. See catarrh.
Gravel. A disease characterized by multiple small calculi (stones or concretions of mineral
salts) which are formed in the kidneys, passed along the ureters to the bladder, and expelled
with the urine. Synonym: kidney stone.
Hectic fever. A daily recurring fever with profound sweating, chills, and flushed appearance??
often associated with pulmonary tuberculosis or septic poisoning.
Hives. A skin eruption of wheals (smooth, slightly elevated areas on the skin) which is redder
or paler than the surrounding skin. Often attended by severe itching, it usually changes its
size or shape or disappears within a few hours. It is the dermal evidence of allergy. See the
discussion under croup; also called cynanche trachealis. In the mid?nineteenth century, hives
was a commonly given cause of death of children three years and under. Because true hives does
not kill, croup was probably the actual cause of death in those children.
Hospital fever. See typhus.
Hydrocephalus. See dropsy.
Hydrothorax. See dropsy.
Icterus. See jaundice.
Inanition. Exhaustion from lack of nourishment; starvation. A condition characterized by
marked weakness, extreme weight loss, and a decrease in metabolism resulting from severe
and prolonged (usually weeks to months) insufficiency of food.
Infection. The affection or contamination of a person, organ, or wound with invading,
multiplying, disease producing germs such as bacteria, rickettsiae, viruses, molds, yeasts,
and protozoa. In the early part of the last century, infections were thought to be the
propagation of disease by effluvia (see above) from patients crowded together. "Miasms"
were believed to be substances which could not be seen in any form??emanations not apparent
to the senses. Such miasms were understood to act by infection.
Inflammation. Redness, swelling, pain, tenderness, heat, and disturbed function of an
area of the body, especially as a reaction of tissue to injurious agents. This mechanism
serves as a localized and protective response to injury. The word ending ?itis denotes
inflammation on the part indicated by the word stem to which it is attached??that is,
appendicitis, pleuritis, etc. Microscopically, it involves a complex series of events,
including enlargement of the sizes of blood vessels; discharge of fluids, including
plasma proteins; and migration of leukocytes (white blood cells) into the inflammatory
focus. In the last century, cause of death often was listed as inflammation of a body
organ such as, brain or lung but this was purely a descriptive term and is not helpful
in identifying the actual underlying disease.
Intussusception. The slipping of one part within another, as the prolapse of one part of
the intestine into the lumen of an immediately adjoining part. This leads to obstruction
and often must be relieved by surgery. Synonym: introsusception.
Jail fever. See typhus.
Jaundice. Yellow discoloration of the skin, whites of the eyes, and mucous membranes, due
to an increase of bile pigments in the blood often symptomatic of certain diseases, such
as hepatitis, obstruction of the bile duct, or cancer of the liver. Synonym: icterus.
Kidney stone. See gravel.
Kings evil. A popular name for scrofula. The name originated in the time of Edward the
Confessor, with the belief that the disease could be cured by the touch of the king of England.
Lockjaw. Tetanus, a disease in which the jaws become firmly locked together. Synonyms:
trismus, tetanus.
Malignant fever. See typhus.
Marasmus. Malnutrition occurring in infants and young children, caused by an insufficient
intake of calories or protein and characterized by thinness, dry skin, poor muscle develop-
ment, and irritability. In the mid-nineteenth century, specific causes were associated with
specific ages: In infants under twelve months old, the causes were believed to be unsuit-
able food,  chronic vomiting, chronic diarrhea, and inherited syphilis. Between one and
three years, marasmus was associated with rickets or cancer. After the age of three years,
caseous (cheeselike) enlargement of the mesenteric glands (located in the peritoneal fold
attaching the small intestine to the body wall) became a given cause of wasting.
(See tabes mesenterica.) After the sixth year, chronic pulmonary tuberculosis appeared to
be the major cause. Marasmus is now considered to be related to kwashiorkor, a severe protein
Meningitis. Inflammation of the meninges (the three membranes covering the brain and spinal
cord), especially of the pia mater and arachnoid??caused by a bacterial or viral infection
and characterized high fever, severe headache, and stiff neck or back muscles. Synonym:
brain fever.
Morbus. Latin word for disease. In the last century, when applied to a particular disease,
morbus was associated with some qualifying adjective or noun, indicating the nature or seat
of such disease. Examples: morbus cordis, heart disease; morbus caducus, epilepsy or
failing sickness.
Neuralgia. Sharp and paroxysmal pain along the course of a sensory nerve. There are many
causes: anemia, diabetes, gout, malaria, syphilis. Many varieties of neuralgia are distin-
guished according to the part affected??such as face, arm, leg.
Paristhmitis. See quinsy.
Petechial fever. See typhus.
Phthisis. See consumption.
Pleurisy. Inflammation of the pleura, the membranous sac lining the chest cavity, with or
without fluid collected in the pleural cavity. Symptoms are chills, fever, dry cough, and
pain in the affected side (a stitch).
Pneumonia. Inflammation of the lungs with congestion or consolidation???caused by viruses,
bacteria, or physical and chemical agents.
Pus. A yellow?white, more or less viscid substance found in abscesses and sores, consisting
of a liquid plasma in which white blood cells are formed and suspended by the process of
Putrid fever. See typhus.
Putrid sore throat. Ulceration of an acute form, attacking the tonsils and rapidly running
into sloughing of the fauces (the cavity at the back of the mouth, leading to the pharynx).
Pyrexia. See dysentery.
Quinsy. A fever, or a febrile condition. An acute inflammation of the tonsils, often lead-
ing to an abscess; peritonsillar abscess. Synonyms: suppurative tonsillitis, cynanche
tonsillaris, paristhmitis, sore throat.
Scarlatina. Scarlet fever. A contagious febrile disease, caused by infection with the
bacteria group. A beta?hemolytic streptococci (which elaborate a toxin with an affinity for
red blood cells) and characterized by a scarlet eruption, tonsillitis, and pharyngitis.
Scrofula. Primary tuberculosis of the lymphatic glands, especially those in the neck. A
disease of children and young adults, it represents a direct extension of tuberculosis into
the skin from underlying lymph nodes. It evolves into cold abscesses, multiple skin ulcers,
and draining sinus tracts. Synonym: king's evil.
Septic. Infected, a condition of local or generalized invasion of the body by disease-causing
microorganisms (germs) or their toxins.
Ship fever. See typhus.
Spotted fever. See typhus.
Suffocation. The stoppage of respiration. In the nineteenth century, suffocation was reported
as being accidental or homicidal. The accidents could be by the impaction of pieces of food
or other obstacles in the pharynx or by the entry of foreign bodies into the larynx (as a
seed, coin, or food). Suffocation of newborn children by smothering under bedclothes may have
happened from carelessness as well as from intent. However, the deaths also could have been
due to SIDS (sudden infant death syndrome), wherein the sudden and unexpected death of an
apparently healthy infant, while asleep, typically occurs between the ages of three weeks and
five months and is not explained by careful postmortem studies. Synonyms of SIDS: crib death
and cot death. It was felt that victims of homicidal suffocation were chiefly
infants or feeble and infirm persons.
Summer complaint. See cholera infantum.
Suppuration. The production of pus.
Tabes mesenterica. Tuberculosis of the mesenteric glands in children, resulting in digestive
derangement and wasting of the body.
Teething. The entire process which results in the eruption of the teeth. Nineteenth-century
medical reports stated that infants were more prone to disease at the time of teething.
Symptoms were restlessness, fretfulness, convulsions, diarrhea, and painful and swollen gums.
The latter could be relieved by lancing over the protruding tooth. Often teething was reported
as a cause of death in infants. Perhaps they became susceptible to infections, especially if
lancing was performed without antisepsis. Another explanation of teething as a cause of death
is that infants were often weaned at the time of teething; perhaps they then died from drinking
contaminated milk, leading to an infection, or from malnutrition if watered-down milk was given.
Tetanus. An infectious, often?fatal disease caused by a specific bacterium, Clostridium tetani,
that enters the body through wounds; characterized by respiratory paralysis and tonic spasms
and rigidity of the voluntary muscles, especially those of the neck and lower jaw.
Synonyms: trismus, lockjaw.
Thrush. A disease characterized by whitish spots and ulcers on the membranes of the mouth,
tongue, and fauces caused by a parasitic fungus, Candida albicans. Thrush usually affects
sick, weak infants and elderly individuals in poor health. Now it is a common complication
from excessive use of broad?spectrum antibiotics or cortisone treatment. Synonyms: aphthae,
sore mouth, aphthous stomatitis.
Trismus nascentium or neonatorum. A form of tetanus seen only in infants, almost invariably
in the first five days of life, probably due to infection of the umbilical stump.
Typhoid fever An infectious, often-fatal, febrile disease, usually occurring in the summer
months characterized by intestinal inflammation and ulceration caused by the bacterium
Salmonella typhi, which is usually introduced by food or drink. Symptoms include prolonged
hectic fever, malaise, transient characteristic skin rash (rose spots), abdominal pain,
enlarged spleen, slowness of heart rate, delirium, and low white blood cell count. The name
came from the disease's similarity to typhus (see below). Synonym: enteric fever.
Typhus. An acute, infectious disease caused by several micro?organism species of Rickettsia
(transmitted by lice and fleas) and characterized by acute prostration, high fever, depression,
delirium, headache, and a peculiar eruption of reddish spots on the body. The epidemic or
classic form is louse borne; the endemic or murine is flea borne. Synonyms: typhus fever,
malignant fever (in the 1850s), jail fever, hospital fever, ship fever, putrid fever, brain
fever, bilious fever, spotted fever, petechial fever, camp fever.
Virus. An ultramicroscopic, metabolically inert infectious agent that replicates only within
the cells of living hosts, mainly bacteria, plants, and animals. In the early 1800s virus
meant poison, venom, or contagion.
Yellow fever. An acute, often?fatal, infectious febrile disease of warm climates caused by
a virus transmitted by mosquitoes, especially Aledes aegypti, and characterized by liver
damage and jaundice, fever, and protein in the urine. In 1900 Walter Reed and others in
Panama found that mosquitoes transmit the disease. Clinicians in. the late nineteenth century
recognized "specific yellow fever" as being different from "malarious yellow fever." The
latter supposedly was a form of malaria with liver involvement but without urine involvement.


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19th Century Medical Terminology